0～3岁反复喘息婴幼儿呼出气一氧化氮水平与哮喘预测指数的相关性

Correlation between level of exhaled nitric oxide and asthma prediction index in infants with recurrent wheezing at 0～3 years old

目的研究0～3岁反复喘息婴幼儿呼出气一氧化氮(FeNO)水平与哮喘预测指数(API)的相关性。方法选取我院儿科门诊2014年11月至2017年3月收治的一年超过3次喘息的婴幼儿患者96例为研究对象,根据API将其分为API阴性组(40例)和API阳性组(56例)。两组患儿均进行皮肤点刺过敏原测试,同时测定FeNO水平、外周血嗜酸性粒细胞百分比(EOS%)水平。比较两组患儿的相关指标。结果 API阳性组患儿的吸入变应原阳性率(57.14%)与食入变应原阳性率(26.79%)均明显高于API阴性组(0.00%、7.50%)(P<0.05);API阳性组患儿的FeNO、EOS%水平明显高于API阴性组(P<0.01);FeNO水平与EOS%为正相关关系(r=0.344,P=0.015)。结论 FeNO水平与API有密切的联系,为临床上检测哮喘提供了具体有效的依据。

Objective To investigate the correlation between level of exhaled nitric oxide （FeNO） and asthma predictionindex （API） in infants with recurrent wheezing at 0-3 years old. Methods A total of 96 cases of infants and children whohad been wheezing for more than3 times a year in our pediatrics department were selected from November 2014 to March2017. According to the API, they were divided into API negative group （40 cases） and API positive group （56 cases）. Bothgroups underwent skin prick allergen test. At the same time, the levels of FeNO and peripheral blood eosinophils （EOS%）were measured. The related indicators of children of the two groups were compared. Results The positive rates of inhalationallergen （57.14%） and the ingestion allergen （26.79%） in the API positive group were significantly higher than those in theAPI negative group （0.00%, 7.50%）（P〈0.05）; the levels of FeNO and EOS% of children in the API positive group weresignificantly higher than those in the API negative group （P〈0.01）; the level of FeNO was positively correlated with EOS%（r=0.344, P=0.015）. Conclusion There is a close relationship between levels of FeNO and API, which provides a specificand effective basis for the clinical detection of asthma.