检测免疫球蛋白水平对慢性乙型肝炎评估的临床价值

Clinical value of detection of immunoglobulin level in the evaluation of chronic hepatitis B

目的研究检测免疫球蛋白水平对慢性乙型肝炎评估的临床应用价值。方法选取我院2015年4月至2017年4月收治的120名慢性乙型肝炎患者,按病情严重性划分为A、B和C组,每组40例。A组患者慢性乙型肝炎症状较轻,B组患者为中型慢性乙型肝炎,C组患者为重型慢性乙型肝炎。同时选取40名健康人作为对照组。按照治疗状况将120例患者分为改善组和恶化组。比较四组免疫球蛋白检测结果,比较慢性乙型肝炎患者的治疗结果,比较改善组与恶化组治疗前、后免疫球蛋白水平。结果 C组的IgG、IgA和IgM水平均高于A组(P<0.05)。且A、B、C组的IgG、IgA和IgM水平均显著高于对照组,差异具有统计学意义(P<0.05)。A、B、C组的痊愈患者占比比较,差异具有统计学意义(P<0.05)。治疗后,按照治疗状况可将120例患者分为改善组(n=53)和恶化组(n=67),且改善组患者的IgG、IgA、IgM水平明显高于恶化组和治疗前,差异具有统计学意义(P<0.05)。结论进行免疫球蛋白水平检测对诊断慢性乙型肝炎具有积极的价值,且具有较高的应用价值,同时其对患者的预后分析也具有较高的应用价值,值得临床推广。

Objective To study the clinical value of detection of immunoglobulin level in the evaluation of chronichepatitis B. Methods A total of 120 patients with chronic hepatitis B admitted in our hospital from April 2015 to April2017 were divided into groups A,B and C according to the severity of the disease, with 40 cases in each group. Patients inthe group A had mild symptoms of chronic hepatitis B, patients in the groupB had moderate chronic hepatitis B, andpatients in the groupC had severe chronic hepatitis B. At the same time, 40 healthy persons were selected as controlgroup. According to the treatment condition, 120 patients were divided into improving group and worsening group. Theresults of immunoglobulin test in four groups were compared, and the results of treatment in the patients with chronichepatitis B were compared. The levels of immunoglobulin before and after treatment in the improving group and theworsening group were compared. Results The levels of IgG, IgA and IgM in the group C were higher than those in thegroup A（P〈0.05）. The levels of IgG, IgA and IgM in the groups A, B and C were significantly higher than those in thecontrol group （P〈0.05）. The proportions of patients recured in the groups A, B andC had a statistically significantdifference（P〈0.05）. After treatment, a total of 120 patients were divided into improving group （n=53） and worsening group（n=67）, and the levels of IgG, IgA and IgM in the improving group were significantly higher than those in the worseninggroup and before treatment, the differences were statistically significant（P〈0.05）. Conclusion Detection of immunoglobulinlevel has positive value in the diagnosis of chronic hepatitis B, and which has high application value. It also has highapplication value in the prognosis analysis of patients. It is worthy of clinical promotion.