双歧杆菌三联活菌散剂和茵栀黄口服液辅助治疗新生儿高胆红素血症的疗效

Efficacy of Bifidobacterium triple viable powder and Yinzhihuang oral liquid in adjuvant treatment of neonatal hyperbilirubinemia

目的探讨双歧杆菌三联活菌散剂和茵栀黄口服液辅助治疗新生儿高胆红素血症的临床效果。方法选取2016年1月至2017年12月我院收治的新生儿高胆红素血症患儿共280例,将其随机分为联合用药组和常规治疗组,各140例。常规治疗组采用双歧杆菌三联活菌散剂配合蓝光照射进行治疗,联合用药组应用菌栀黄口服液联合双歧杆菌三联活菌散配合蓝光照射进行治疗,对比两组患儿的临床治疗效果及不良反应发生情况。结果联合用药组患儿的治疗总有效率为80.00%,高于常规治疗组患儿的51.43%,差异具有统计学意义(P<0.05)。联合用药组患儿的不良反应总发生率为0.71%,显著低于常规治疗组患儿的7.14%,差异有统计学意义(P<0.05)。结论应用菌栀黄口服液联合双歧杆菌三联活菌散对高胆红素血症患儿进行治疗,其临床效果较好,可以有效改善患儿症状,且安全性较高。

Objective To explore the clinical effect of Bifidobacterium triple viable powder and Yinzhihuang oral liquidin adjuvant treatment of neonatal hyperbilirubinemia. Methods From January 2016 to December 2017, 280 cases ofchildren with neonatal hyperbilirubinemia in our hospital were selected and randomly divided into combination treatmentgroup and conventional treatment group, with 140 cases in each group. The conventional treatment group was givenBifidobacterium triple viable powder with blue light irradiation treatment, the combination treatment group was givenBifidobacterium triple viable powder and Yinzhihuang oral liquid with blue light irradiation treatment. The clinical effectsand the occurrences of adverse reactions of the two groups were compared. Results The total effective rate of treatment inthe combination treatment group was 80.00%, which was higher than 51.43% in the conventional treatment group, thedifference was statistically significant（P〈0.05）. The total incidence of adverse reactions in the combination treatment groupwas 0.71%, which was significantly lower than 7.14% in the conventional treatment group, the difference was statisticallysignificant （P〈0.05）. Conclusion Bifidobacterium triple viable powder and Yinzhihuang oral liquid in the treatment ofneonatal hyperbilirubinemia has a good clinical effect, can effectively improve the symptoms of children, with high safety.