维生素D缺乏与冠状动脉粥样硬化性心脏病的相关性研究进展

The research progress of the correlation between vitamin D deficiency and coronary atherosclerotic heart disease

维生素D是机体内维持钙磷平衡的重要有机物质，其与冠状动脉粥样硬化性心脏病（简称冠心病）的发生和发展也密切相关。维生素D缺乏可通过激活炎性反应、减弱血管内皮的保护作用、激活。肾素-血管紧张素一醛固酮系统、损害胰岛素功能、引发糖脂代谢异常及体质量增高等机制导致冠心病的发生。补充维生素D对冠心病的影响仍需要大规模的临床试验来证实。

Vitamin D is an important organic substance in the body to maintain the balance of calcium and phosphorus, and it is also closely related to the occurrence and development of coronary atheroselerotic heart disease （referred to as coronary heart disease）. Vitamin D deficiency can lead to the occurrence of coronary heart disease by activating the inflammatory response, weakening the protective effect of the vascular endothelium, activating the renin-angiotensin-aldosterone system, impairing insulin function, triggering abnormal glucose and lipid metabolism, and increasing body weight. The effect of vitamin D supplementation on coronary heart disease still requires large-scale clinical trials to confirm.