摘要
目的:探讨诱发Stevens-Johnson综合征(SJS)/中毒性表皮坏死松解症(TEN)的可能原因及防治方法。方法:分析本例SJS/TEN患者的临床表现、实验室检查、血药浓度监测及药物相关基因检测结果,同时通过文献检索,对该病例进行分析总结。结果:CYP2C19基因型为*1/*2,丙戊酸、苯巴比妥可能为SJS并最终发展为TEN的诱因。结论:TEN的诱因较多,死亡率高,感染、免疫性疾病与患者死亡率有较大的相关性。
Objective: To investigate the possible causes, prevention and treatment of Stevens-Johnson syndrome (SJS) /toxic epidermal necrolysis (TEN) . Methods: The clinical manifestations, laboratory tests, blood drug concentration monitoring and drug-related gene test results of the case of SJS/TEN were analyzed. Meanwhile, the literature was searched, and the case was analyzed and summarized. Results: CYP2C19 genotype was * 1/* 2. Valproic acid and phenobarbital may be the inducement of SJS and TEN. Conclusion: SJS/TEN has many causes and high mortality. Infection and immune diseases are closely related to the mortality of patients.
作者
李静
李燕
黄铃
袁明勇
LI Jing, LI Yan, HUANG Ling, YUAN Ming-yong(Department of Pharmacy, The First Affiliated Hospital of Chengdu Medical College, Chengdu 610500,China)
出处
《临床药物治疗杂志》
2018年第9期78-81,共4页
Clinical Medication Journal