甲状腺癌患者血清一氧化氮水平动态观察及其意义

Centinuous Observation of Serum NO Level in the Patient with Thyroid Carcinoma and Its Significance

目的 :探讨甲状腺癌患者手术前后血清一氧化氮 (NO)水平变化的意义。方法 :采用微盘比色法对 16例甲状腺癌术前、术后 ,16例甲状腺腺瘤 ,16例健康人血清NO水平进行检测。结果 :(1)甲状腺癌患者血清NO水平显著高于良性病变和健康对照组 (P <0 .0 1) ;(2 )甲状腺癌术后 5d血清NO水平低于术前 (P <0 .0 1)。结论 :甲状腺癌的发生与发展可能与血中NO水平升高有关。NO的检测对探讨甲状腺癌发生机理、病情判断及指导治疗有一定价值。

Objective: To explore the significance of the changes of serum NO levels of pre and post operation in the patients with thyroid carcinoma.Methods: Adopted colorimetry to examine serum NO levels for pre and post operation in 16 patients with thyroid carcinoma,in 16 pationts with thyrophyma,and in 16 healthy persons,respectively.Results:1. Serum NO level of patients with thyroid carinoma was obviously higher than both levels of patients with benign tumor and of healthy persons( P &lt;0.01).2.At five days after operation,Serum NO level was lower than that of pre operation.Conclusion: pathogenesis of thyroid carcinoma and its development are associated with the increase of serum NO.Examination of serum NO level is of some value for inrestigation of the pathogenetic mechanism,diagnosis,and tualment of thyroid carcinoma.