善宁抢救大咯血24例临床观察

Salvage efficacy of Sandostatin for Heavy Hemoptysis

目的 :评价善宁对大咯血抢救的疗效。方法 :传统药物抢救 2 4例无效或有禁忌的大咯血用善宁抢救为治疗组 ,2 8例 3年前具有类似大咯血用传统药抢救为对照组。观察用药后 6h、2 4h、72h的止血率和 1周后的复发率。结果 :治疗组总有效率为 79.2 %与对照组 6 7.9%无明显差异 (P >0 .0 5 ) ,但 6h内止血率 5 8.3%较对照组 2 8.6 %有显著差异 (P <0 .0 5 ) ,1周后复发率 12 .5 %与对照组 42 .9%也有显著差异 (P <0 .0 5 )。结论 :善宁对大咯血抢救安全、有效 。

Objective: To evaluate the efficacy of Sandostatin in salvaging heavy hemoptysis. Methods:24 patients with heavy haemoptysis who were taboo against or did not respond to the traditional drugs (Hypophysine?Regitin and Procaine), were treated with Sandostatin as test group.The other 28 patients with heavy hemoptysis were treated with the traditional drugs as control group. The response rate of stanching in 6 hours?24 hours?and 72 hours and the relapse rate after one week were determined. Results:The total response rate was 79.2% in the test group and 67.9% in the control group with no significant difference ( P &gt;0.05).But 6 hours stanching rate was 58.3% in the test group compared with 28.6% in the control group( P &lt;0.059.After one week the relapse rate was significantly lower in the test group(12.5%)than that in the control group(42.9%)( P &lt;0.05).Conclusion:Sandostatin in the salvaging heavy haemoptysis is effective?reliable,and safe.It could be one of ideal candidate drugs.