测定胸腹水TNFα及IL-6的意义

The Significance of Assays of TNFαand IL-6 in Pleural and Peritoneal Effusions

目的 :观察胸、腹水TNFα及IL 6的水平及意义。方法 :116例伴有胸腹水的患者按疾病性质分为四组 ,采用放射免疫法测定TNFα及IL 6水平。结果 :漏出液组TNFα及IL 6分别为 2 1.4± 4.9nmol/L、0 .2 3± 0 .12ng/ml,炎症、肿瘤、结核三组渗出液TNFα及IL 6明显增高 ,尤以结核性胸水组增高更显著 (P <0 .0 1)。治疗后测定 2 2例患者胸腹水TNFα及IL 6 ,91% (2 0 /2 2 )病例浓度降低。结论 :测定胸腹水TNFα及IL 6可以鉴别积液性质 ,上述两种细胞因子在炎症、肿瘤、结核等疾病过程中具有重要作用 。

Objective: To analyze the significance of the change of levels of TNFαand IL 6 in pleural and peritoneal effusions. Methods: One hundred and sixteen patients with pleural or peritoneal effusion were divided into 4 groups according to the nature of diseases and the levels of TNFαand IL 6 that were determined with radioimmunoassay. Results: The levels of TNFαand IL 6 in the transudate group were 21.4±4.9 mmol/L and 0.23±0.12 ng/ml, respectively. In contrast, those levels in the other three exude groups including arthritis, tumor, and tuberculosis were notably increased, especially in tubercles pleural effusion( P &lt;0.01). After treatment, TNFαand IL 6 were decreased. Conclusion: Determination of TNFαand IL 6 in pleural and peritoneal effusions can differentiate the character of the effusions. The two cytokines might play a significant role in the diseases with arthritis, tumor, and tuberculosis.