摘要
目的 :探讨转化生长因子 β1(TGF β1)在胃癌发生发展及转移中的作用。方法 :采用免疫组化S P法检测了5 4例大肠癌、10例正常大肠粘膜内TGF β1的表达。结果 :(1)大肠癌组织中TGF β1的阳性表达率 (10 0 % )显著高于正常肠粘膜 (10 % ) (P <0 .0 1) ;(2 )TGF β1的表达强度在淋巴结转移组显著高于无淋巴结转移组 (P <0 .0 5 ) ;(3)TGF β1的表达与大肠癌的组织类型无关 (P >0 .0 5 )。结论 :TGF β1表达参与了肠癌发生发展和转移 。
Objective: To study the role of TGF β 1 in the development and progress of colorectal carcinoma. Methods: Specimens of 54 colorectal carcinomas and 10 normal colorectal mucous were examined for TGF β 1 expression with means of S P immunohistochemical staining. Results: (1) The positive rate of TGF β 1 expression was 100% in the patients with colorectal carcinoma that was significantly higher than the rate in the normal intestinal mucosa (10%) ( P <0.001). (2) The expression intensity of TGF β 1 was related to lymph node metastasis of colorectal carcinoma. Conclusion: TGF β 1 overexpression may be involved in the development and metastasis of colorectal carcinoma.
出处
《实用临床医学（江西）》
CAS
2002年第A01期13-14,共2页
Practical Clinical Medicine
关键词
肠癌
TGFΒ1
转移
stomach neoplasms
TGF β 1
metastasis
