多脏器危象综合征、机体损伤反应综合征细胞生物学机制:肥大细胞与巨噬细胞的作用——“机体损伤反应综合征”问题再探

Cellular Biologic Mechanism of the Actions of Mast Cells in Macrophages in Multiple Organ Crisis Syndromc"MOCS" and Body Injury Response Syndrome"BIRS

通过对肥大细胞来源、功能、分化、调节、激活及其分泌媒介物 (细胞激活因子、中性蛋白分解酶、变性蛋白分解酶 ,脂类产物 ,组织胺 ) ,以及巨噬细胞功能等细胞生物学作用讨论 ,并基于生命多系统时空论 (也称广义生命时空场论 )学说 ,按照“机体损伤反应综合征”SD1D2 F的四阶段说观点 ,阐述了肥大与巨噬细胞在多脏器危像 ,机体损伤反应综合征中的细胞生物学机制。

The cellular biologic mechanism of the actions of mast cells(origins,actions,differentiates,regulations,activations and its mediator products cytokine products,neutral proteascs,proteoglycans,Lipid products),and the actions of macrophages etc was discussed in this article. Base on the theory'Multiple time space theory/MTS'(also called'General life time space field theory/LTSF') and the view of'SD,D,F'four periods of body injury response syndrome (BIRS), the authors for the first time proposed the molecular biological mechanism of the action of mast cells and macrophages in multiple organ crisis syndrome(MOCS)and BIRS.