工作相关肌肉骨骼疲劳与损伤相关生物标志物研究进展

Research progress on related biomarkers of work-related musculoskeletal fatigue and disorders

为探索工作相关肌肉骨骼疲劳与损伤生物标志物,总结分析相关标志物研究现状,本文以"工作相关肌肉骨骼疲劳与损伤,生物标志物"(中英文)为检索词,在Pub Med、Springerlink、Web of Science、万方数据、中国知网数据库检索1997—2017年相关文献总计257篇,对其中62篇有效文献进行汇总分析。工作相关肌肉骨骼疲劳与损伤发生过程存在代谢、氧化、炎症等生物化学改变,不同阶段可能涉及特定标志物的特征性改变。根据肌肉骨骼损伤(Musculoskeletal disorders,MSDs)已有发生机理将相关标志物分为4类:代谢性标志物、氧化应激标志物、炎性标志物、疼痛相关标志物。各类标志物的显著性改变发生在疲劳与损伤进程的相同或不同阶段,大部分标志物处于共存状态。联合标记物比单个标记物更能预测肌肉骨骼疲劳与损伤。

In order to explore the related biomarkers of work-related musculoskeletal fatigue and disorders,and summarize the research progress of the related markers,a computer-based online search is conducted in Pub Med,Springerlink,Web of Science,China Info,CNKI with the key words of ＂work-related musculoskeletal fatigue and disorders,biomarkers＂ in both Chinese and English from 1997 to 2017,and 62 valid literatures are summarized and analyzed from the 257 related literatures collected. There are biochemical changes such as metabolism,oxidation,inflammation and other biochemical changes in the process of work-related musculoskeletal fatigue and disorders,which may involve the characteristic changes of specific markers at different stages.According to the existing mechanisms of musculoskeletal disorders（MSDs）,the related markers are divided into four categories：metabolic markers,oxidative stress markers,inflammatory markers and pain related markers. Significant changes in various markers occur at the same or different stages of fatigue and injury processes,and most of the markers are in coexistence.Combined markers are more predictive of musculoskeletal fatigue and disorders than single markers.