摘要
本文用紫外分光光度计二阶导数光谱法测定6名健康志愿受试者(?)单剂量po氧氟沙星国产、进口两种片剂后的尿药浓度,进行药物动力学和生物利用度研究。国产和进口氧氟沙星片药物动力学参数分别为:T_(1╱2):7.41±1.44和7.41±1.07(h),K:0.0978±0.03和0.0971±0.02(h^(-1)),相对生物利用度为99.57%
The paper reported the determination of ofloxacin in urine by second derivative spectrophotometry. Pharmacokinetics and bioavailability of ofloxacin were studied in 6 healthy volunteers after oral administration, and a comparison was made between different tablets come from home and Japah. Pharmacokinetic parameters of the two ofloxacins were: T1/2: 7. 4 ± 1. 44 and 7. 4± 1. 07 (h) ; K: 0.0978 + 0.03 and 0. 0971±0. 02(h-1); comparative bioavailability was 99. 57%,
出处
《中国临床药学杂志》
CAS
1994年第3期8-10,共3页
Chinese Journal of Clinical Pharmacy
关键词
氧氟沙星
二阶导数光谱
尿药浓度
生物利用度
ofloxacin second derivative spectroscopy urinary concentration bioavailability