棓酰苯胺与其他抗心律失常药合用对电刺激家兔左心室致颤阈的影响

EFFECTS OF GALLANILIDE COMBINED WITH OTHER ANTIARRHYTHMIC DRUGS ON ELECTRICALLY INDUCED VENTRICULAR FIBRILLATION THRESHOLD IN RABBITS

iV桔酰苯胺(Gal)能显著提高电刺激兔左心室致颤阈(VFT),且在1～6mg╱kg剂量范围内呈直线相关。高、低剂量Gal分别与七种抗心律失常药合用的结果表明,Gal 1.4和2.0mg/kg与Apr 1.0mg╱kg,Gal 1.7mg╱kg与Lid 5mg/kg,Gal 1.4mg/kg与phen 5mg/kg,Gal 1.0mg╱kg与prop 0.2mg╱kg合用均有相加作用,Gal 2.0mg╱kg与Lid 5mg/kg或phen 5mg╱kg合用则有增强 作用。

The electrically induced ventricular fibrillation threshold (VFT)in anesthetiged rabbits increased in linear relationship with the dose of Gallanilide (iv 1-6mg/kg). 5 Kinds of antiarrhythmic drug, Lidocaine (10 mg/kg), Guinidine (10 mg/kg), Procainamide (40 mg/kg), Sodium Phenytoin (10 mg/kg) and Aprindine(2 mg/kg)increased VFT significantly but Propranolol (0. 2 mg/kg)and Diazepamd mg/kg)did not do so.The effects of Gallanilide in combination with other antiarrhythmic drugs were studied. The rusults showed that the Gallanilide (1. 7mg/kg) and Lidocaine (5mg/ kg),Gallanilide(1. 4mg/kg)and Sodium Phenytoin(5mg/kg),Gallanilide(1mg/kg) and Propranolol (0. 2mg/kg),Gallanilide(1. 4mg/kg)and Aprindine(1mg/kg),as well as Gallanilide(2mg/kg)and Aprindine(1mg/kg)had simply additive,While the effects of Gallamilide(2mg/kg)with Lidocaine(5mg/kg)or Sodium Phenytoin(5mg/ kg)had potentiation.