白细胞介素-6在小鼠体内的药动学研究

THE PHARMACOKINETICS OF INTER LEUKIN-6 IN RATS

本文应用生物活性测定法,在小鼠体内对白细胞介素-6静脉、腹腔给药,进行了药动学研究。结果表明:静脉给药后,白细胞介素-6在小鼠体内分布较快,T_(1╱2)α=1.5min,消除也较快,T_(1╱2)β=0.38h,体内停留时间较短,不适于临床治疗;腹腔给药后缓慢吸收,Tp=0.73h,Cp=5.9×10^(?)u/ml,分布及消除较静脉给药慢,T_(1╱2)α=0.67h,T_(1/2)β=0.67h;T_(1╱2)β=2.9h,给药后6h内,体内仍保留一定量的药物,适于临床治疗。

The pharmacokinetics of intravenously and intraperitonealy administered inter-leukin-6 (IL-6) were studied in rats by the biological activation assay. The results showed that IL-6 was distributed and eliminated rapidly by rats after intravenous administration. T1/2α= 1. 5min, T1/2β=0. 38h. The time of IL-6 in rats bodies was short, so intravenous administration isn’t suitable for clinical therapy. After intraperitoneal administrtion, IL-6 was absorbed slowly by rats and the rates of distribution and elimination were higher than that of intravenous administration, there were still some amount of IL-6 left in rats bodies after 6 hours, therefore intraperitoneal administration fits into clinical therapy.