摘要
本文报道了硝苯吡啶在家兔体内不同给药时间的药动学变化。家兔7只,于0:00,6:00,12:00,18:00四个不同的时间给药,剂量为10mg╱kg,血药浓度用HPLC法测定。结果表明硝苯吡啶的血药浓度在0:00最高,AUC最大,为156.90μg·(ml·min)^(-1);MRT最长为4.39h。
The chronopharmacokinetic of nifedipine was investigated in rabbits. A single dose of nifedipine 10 mg/kg was given respectively at 0 : 00,6 : 00,12 : 00,18 : 00 in 7 rabbits. The plasma drug concentration were determined by HPLC. The results indicated that the circadian rhythms in the pharmacokinetic of nifedipine were demonstrated. The plasma levels of nifedipine at 0 : 00 were the highest,AUC was the largest,MRT was the longest.
出处
《中国临床药学杂志》
CAS
1995年第4期1-3,10,共4页
Chinese Journal of Clinical Pharmacy
