调Q开关Nd：YAG激光治疗色素性皮肤病疗效及对皮肤屏障功能的影响

Clinical efficacy of Q-switched laser on pigmented dermatoses and its detection of skin physiological function

目的探讨调Q开关Nd：YAG激光对色素性皮肤病患者甲皱微循环和皮肤屏障功能的影响。方法2015年7月至2016年4月，江苏连云港市第一人民医院皮肤科对色素性皮肤病患者100例采用调Q开关Nd：YAG激光治疗，对患者治疗前后皮损处皮脂含量、皮肤含水量、皮肤失水量进行检测，对患者治疗前后甲皱微循环进行观察，对患者疗效进行观察和随访。结果100例色素性皮肤病患者治疗后有效率94．00％。未出现色素减退和瘢痕病例，复发率低。色素性皮肤病患者治疗后皮损部位患者皮脂含量、皮肤含水量、甲皱微循环明显改善，和治疗前比较，差异有统计学意义（P〈0．05）。结论调Q开关Nd：YAG激光可改善微循环障碍，从而调节患者皮肤屏障功能。

Objective To investigate the effect of Q laser on microcirculation structure and skin barrier function of subcutaneous tissue in patients with pigmented dermatosis. Methods The Q laser was used in treatment of 100 cases of pigmented skin diseases, and the skin barrier function was detected before and after treatment in patients with lesions, including sehum content, transepidermal water loss of skin moisture; difference of skin barrier function in patients was analyzed before and after treatment; the structural change of microeireulation were observed before and after treatment of skin tissue; the clinical curative effects of patients after treatment were analyzed, and then the patients were followed up to evaluate the recurrence rate. Results After the treatment of patients with skin lesions, barrier function was compared with a significant difference. Compared with before treatment, rise, oil content of skin lesions in patients with skin moisture content, transepidermal water loss of skin moisture of the patient improved obviously after treatment. The effective rate was 94% in the 100 cases of skin diseases. No hypopigmentation or scar occurred in the patients. And the follow-up showed that the recurrence rate was relatively low. Conclusions Adjusted Q laser may participate in the improvement of microcirculatory disturbances through special mechanisms, so as to regulate the skin barrier function of patients.