青鹏软膏治疗成人慢性湿疹Meta分析

Qingpeng ointment for treafment of chronic eczema： a Meta analysis

目的探讨外用青鹏软膏治疗成人慢性湿疹的疗效和安全性。方法2018年5月，苏州科技城医院皮肤科利用南京医科大学图书馆网站，通过计算机检索重庆维普数据库（2000－2017年）、中国知网（2000－2017年）、万方数据库（2000－2017年）关于青鹏软膏治疗慢性湿疹病例对照研究。采用Cochrane协作网提供RevMan5.3软件进行Meta分析。为保证数据可靠性仅选用三级医院发表文献。试验组为外涂青鹏软膏，对照组为外涂糖皮质激素乳膏，如弱效丁酸氢化可的松乳膏以及中强效糠酸莫米松、丙酸氟替卡松、卤米松、曲安尿素乳膏、派瑞松等，比较二者治疗慢性湿疹疗效。结果共纳入7篇随机对照试验文章，500例患者中试验组258例，对照组242例。青鹏软膏与糖皮质激素组疗程为2周、4周，OR值（95%CI）分别为0.95（0.52，1.72）、0.80（0.29，2.25），两组比较差异无统计学意义（P＝0.54和P＝0.60）。青鹏软膏组与丁酸氢化可的松比较，OR值（95%CI）为0.75（0.31，1.82）；与中强效激素组比较，2周及4周疗效差异无统计学意义0.99（0.50，1.95）、1.10（0.18，6.53）（P＝0.38和P＝0.36）。青鹏软膏外涂皮损处无明显不良反应。结论青鹏软膏治疗慢性湿疹安全有效，与（弱、中强效）激素组相比，疗效差异无统计学意义，不良反应小，可作为治疗慢性湿疹的外用药之一。

ObjectiveTo investigate the efficacy and safety of Qingpeng ointment treating adult chronic eczema.MethodsIn May 2018, cases of chronic eczema were searched in databases of Chongqing Weipu （2000-2017）, China Knowledge Resource Integrated Database （2000-2017） and Wanfang （2000-2017） through Nanjing Medical University Library website in the Department of Dermatology, Suzhou Science and Technology Town Hospital. RevMan5.3 software provided by Cochrane collaboration was used for Meta-analysis. To ensure data reliability, only the documents from Grade three hospitals were included. The experimental group was treated with Qingpeng ointment, while the control group was treated with weakly potent glucocorticosteroid, such as glucocorticoid cream, or moderately potent glucocorticosteroid, such as hydrocortisone butyrate cream, fluticasone propionate, halometasone and triamcinolone urea cream.Results Totally, 7 randomized controlled trials, among which 258 patients in the trial group and 242 patients in the control group were included. The odds ratio （OR） values of Qingpeng ointment relative to glucocorticoid group at 2 and 4 weeks were 0.95 （0.52, 1.72） and 0.80 （0.29, 2.25） respectively, showing no significant difference （P=0.54 and P=0.60, respectively, 95% Confidence Interval）. Compared with hydrocortisone butyrate treating group, the OR value was 0.75 （0.31, 1.82）. And compared with moderately potent mometasone furoate, there was no significant difference in two-week and four-week treatment groups 0.99 （0.50, 1.95）, 1.10 （0.18, 6.53） （P=0.38 and P=0.36）. No obvious adverse reactions were found in Qingpeng ointment treated group.ConclusionsQingpeng ointment is safe and effective in treating chronic eczema. There is no significant difference between Qingpeng ointment treating group and glucocorticosteroid treating group. Qingpeng ointment can be used as a safe external medicine for the treatment of chronic eczema.