耐甲氧西林金黄色葡萄球菌的耐药机制

Resistance mechanisms of methicillin-resistant Staphylococcus aureus

近年来,由于院内感染控制、抗菌药物使用严格管理等因素,耐甲氧西林金黄色葡萄球菌（MRSA）的检出率有所下降,但耐药形势仍十分严峻.近来研究发现,MRSA除了携带常见的mecA基因外,小部分携带mecA同源基因mecC基因,新耐药机制为MRSA的检测带来了新的挑战.本文对MRSA主要耐药机制包括青霉素结合蛋白、mecA基因、mecC基因、fem基因家族、主动外排系统等进行综述.

In recent years, the detection rate of methicillin-resistant Staphylococcus aureus （MRSA） has declined because of the factors such as nosoeomial infection control and the strict administration of antibacterial drugs. However, the drug resistance situation is still severe. Recent studies have found that in addition to the common mecA gene, MRSA carries a mecA homologue gene-mecC gene. The new mechanism of drug resistance has brought new challenges to the MRSA detection. In this article, the main resistance mechanisms of MRSA including penicillin-binding protein, mecA gene, mecC gene, fern gene family and active efflux system are reviewed.