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复视明胶囊的抗炎和镇痛作用 被引量:3

Anti-inflammatory and analgesic effects of Fushiming Capsules
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摘要 目的研究复视明胶囊的抗炎、镇痛作用。方法将昆明种小鼠随机分为模型组、阳性对照组、羟苯磺酸钙组及复视明胶囊低、中、高剂量组,采用二甲苯致小鼠耳肿胀和棉球埋置小鼠皮下致肉芽肿模型,以阿司匹林作为阳性对照,观察不同剂量复视明胶囊的抗炎作用。采用醋酸扭体法和热板法,以布洛芬作为阳性对照,观察不同剂量复视明胶囊的镇痛效果。结果与模型组比较,复视明胶囊低、中、高剂量组对二甲苯所致小鼠耳肿胀有明显抑制作用(P<0.01),对小鼠棉球肉芽肿具有明显的抑制作用(P<0.01),可减少小鼠扭体反应次数(P<0.05或P<0.01);在90min时复视明胶囊中、高剂量组可提高小鼠热板法所致的痛阈值(P<0.05)。结论复视明胶囊具有显著的抗炎、镇痛作用。 Objective To study the anti-inflammatory and analgesic effects of Fushiming Capsules (FSMC). Methods Healthy and adult Kunming mice were randomly divided into model group,positive drug control group,calcium dobesilate group and FSMC′s high,middle and low dose groups.The anti-inflammatory effects were observed by the methods of dimethyl xylene induced ear edema in mice and cotton pellet-induced granuloma model (aspire as positive drug).The analgesic effects of different doses of FSMC were observed by hot-plate test and acetic acid writhing test (ibuprofen as positive control). Results Compared with the model group,low,middle and high doses of FSMC had significant inhibitory effects on the ear edema induced by dimethyl xylene ( P 〈0.01);compared with the model group,the low,middle and high dose groups of FSMC showed significant inhibitory effects on the pellet-induced graunloma in mice ( P 〈0.01).The low,middle and high dose groups of FSMC can reduce the times of mice writhing ( P 〈0.05 or P 〈0.01).At 90 min,the middle and high dose groups could prolong the pain threshold of mice by thermal stimulation ( P 〈0.05). Conclusion The FSMC has significant effects on anti-inflammatory and analgesic.
作者 许璐 何萌杉 张明科 王四旺 XU Lu;HE Mengshan;ZHANG Mingke;WANG Siwang(Institute of Materia Medica,School of Pharmacy,Air Force Medical University,Xi′an 710032,China;Xi′an Lejian Biotechnology Limited Company,Xi′an 710032,China)
出处 《西北药学杂志》 CAS 2018年第6期771-774,共4页 Northwest Pharmaceutical Journal
基金 陕西省科技统筹创新工程项目(编号:2017ZDCXLSF-01-01)
关键词 复视明胶囊 抗炎 镇痛 Fushiming Capsules anti-inflammatory analgesic
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