左氧氟沙星注射液致不良反应的影响因素分析

Analysis of the influential factors of adverse drug reactions caused by Levofloxacin Injections

目的探讨左氧氟沙星注射液致不良反应(ADR)的发生情况及相关影响因素,提高临床用药的安全性。方法回顾性分析2012～2016年左氧氟沙星注射液治疗患者的临床资料,统计ADR发生的特点和发生率,采用单因素分析和多因素Logistic回归分析危险因素。结果共发生ADR病例62例,发生率为2.80%。多因素Logistic回归显示,ADR的独立危险因素有年龄(OR=1.583,95%CI:1.348～1.762)、过敏史(OR=2.157,95%CI:1.798～2.684)、给药途径(OR=1.651,95%CI:1.459～1.965)、用药剂量(OR=1.827,95%CI:1.572～2.106)、疗程(OR=1.736,95%CI:1.521～2.037)和合并用药(OR=1.715,95%CI:1.492～1.981)。结论左氧氟沙星注射液ADR临床症状较轻,但累及器官和系统广,并与年龄、过敏史、给药途径、用药剂量、疗程和合并用药有关。临床医生须根据这些因素选择合理用药方案,以降低ADR的发生。

Objective To explore the adverse drug reactions （ADR） of Levofloxacin Injections and related risk factors,and to improve the clinical medication safety. Methods The clinical data of cases treated with Levofloxacin Injections between 2012 and 2016 were reviewed.The kinds of ADR and their incidence were investigated.And the risk factors were analyzed by single factor and multivariate logistic regression analysis. Results The ADR were found in 62 cases and the incidence of ADR was 2.80%.Multivariate logistic regression analysis showed that independent risk factors for ADR were as follows：age （ OR =1.583,95%CI：1.348-1.762）,allergic history （ OR =2.157,95%CI：1.798-2.684）,route of administration （OR =1.651,95%CI：1.459-1.965）,dosage of medication （ OR =1.827,95%CI：1.572-2.106）,course of treatment （ OR =1.736,95%CI：1.521-2.037） and drug combination （ OR =1.715,95%CI：1.492-1.981）. Conclusion The Levofloxacin Injections had milder adverse reactions,involving many organs and systems,which related to age,allergic history,route of administration,dosage of medication,course of treatment and drug combination.Clinicians must choose reasonable medication plan based on these factors in order to reduce the incidence of ADR.