老年慢性阻塞性肺疾病急性加重期合并细菌感染前白蛋白与细菌感染生物标志物的相关性研究

Correlation Study between Serum Prealbumin and Biomarkers of Bacterial Infection in Elderly AECOPD Patients Complicated with Bacterial Infection

目的:研究老年慢性阻塞性肺疾病急性加重期(AECOPD)合并细菌感染患者血清前白蛋白(PA)与细菌感染生物标志物的相关性,探讨PA在判断AECOPD合并细菌感染中的意义。方法:选择2015年7月—2017年12月我院206例老年AECOPD合并细菌感染患者,测量入院时及痊愈时(出院前) PA、降钙素原(PCT)、白细胞总数(WBC)、中性粒细胞比例(N%)水平,采用t检验分析差异性;采用Spearman相关分析PA与PCT、WBC、N%的相关性。结果:入院时及痊愈时PA、PCT、N%差异均有统计学意义(P <0. 05),而入院时及痊愈时WBC差异无统计学意义;入院时及痊愈时PA与PCT均具有相关性(P <0. 05)。结论:AECOPD合并细菌感染时PA明显降低,感染控制后明显升高,PA变化与PCT变化具有显著负相关,PA可作为提示老年AECOPD合并细菌感染的敏感指标。

Objective：To study the relationship between serum prealbumin （PA） and biomarkers of bacterial infection in elderly AECOPD patients complicated with bacterial infection. To explore the significance of PA in the diagnosis of AECOPD complicated with bacterial infection. Methods ： A retrospective study was performed at our Hospital in elderly AECOPD patients complicated with bacterial infection, patients admitted from July 2015 to December 2017 were included. We extracted patients＇ documents from the electronic medical record system. 206 cases of elderly AECOPD patients complicated with were included. At admission and recovery （before discharge）, the levels of PA, procalcitonin （PCT）, WBC and neutrophil ratio （N%） were measured. T test was used to analyze the difference, and the correlation score of Spearman was used. Results ： There was a significant difference in PA, PCT, N% （P 〈 0.05 ）, but there was no significant difference in WBC at admission and recovery （P 〉 0.05 ）. There was a correlation between PA and PCT at admission and recovery （P 〈 0.05 ）. Conclusion ： PA decreased significantly in elderly AECOPD patients complicated with bacterial infection and increased significantly after infection control. There was a significant negative correlation between PA and PCT changes. PA may be used as a sensitive index to suggest that elderly AECOPD patients complicated with bacterial infection.