乳腺非典型增生与乳腺癌相关危险因素分析

Risk factors between mammary atypical hyperplasia and breast cancer

目的探讨乳腺非典型增生与乳腺癌相关危险因素，进一步查找乳腺非典型增生进展到乳腺癌过程中起关键作用的因素，并结合mtDNA的体细胞突变进行研究，为乳腺癌的早期诊断和预防提供临床及基因学依据。方法选取2013年1月至2014年10月期间收治在昆明市第一人民医院乳腺科组织病理学诊断为乳腺非典型增生患者（111例）作为观察组，同期诊断为原发乳腺癌患者（156例）作为对照组，采用SPSS19．0软件进行logistic回归分析探讨乳腺非典型增生发展至乳腺癌的相关危险因素。结果年龄、初潮年龄、是否绝经及流产均为乳腺非典型增生及乳腺癌的高危因素，特别是年龄、绝经与否及流产次数这3个方面关系更为密切。结论患者年龄、绝经与否及流产次数在乳腺非典型增生发展至乳腺癌过程中可能扮演重要角色，因此可在这些方面采取预防措施。

Objective To find out the correlation between mammary atypical hyperplasia and breast cancer. To pinpoint the pivotal factors in the development of atypical hyperplasia to breast cancer. To provide clinical and genic clues for early diagnosis and prevention of breast cancer combined with somatic mutation in mitochondria DNA. Methods 111 patients with mammary atypical hyperplasia and 156 patients with primary breast cancer were enrolled respectively from Jan. 2013 to Oct. 2014. Logistic regression analysis using SPSS 19.0 was performed to study the factors in the development of mammary atypical hyperplasia to breast cancer. Results Univariate analysis results showed a high correlation of breast cancer with age, menarche age, menopause age and times of abortion. Multivariate analysis results suggested that age, menopause age and abortion times were high risk factors of breast cancer. Conclusion Age, menarche age, menopause age and abortion times are significantly correlated with breast cancer and may be play key roles in development of mammary atypical hyperplasia to breast cancer.