石墨烯及其衍生物修复周围神经缺损的研究进展

Research progress of graphene and its derivatives in repair of peripheral nerve defect

目的对石墨烯及其衍生物在修复周围神经缺损领域的应用现状及进展进行综述。方法广泛查阅近年来国内外相关文献,并进行总结分析。结果体外细胞培养及动物体内实验证实,石墨烯及其衍生物能够有效促进细胞黏附、增殖、分化与神经突的延长。与传统材料相比,其具备良好的导电性、优异的机械性能、较大的比表面积、良好的生物相容性等优势,制备的三维多孔支架能够进一步提高神经修复的效果。结论石墨烯及其衍生物在体内的代谢途径及长期存留体内的反应尚未明确,如何更好地调控其生物降解性、解释其与细胞间确切的电偶联反应机制尚需进一步探索研究。

Objective To review the research progress of graphene and its derivatives in repair of peripheral nerve defect. Methods The related literature of graphene and its derivatives in repair of peripheral nerve defect in recent years was extensively reviewed. Results It is confirmed by in vitro and in vivo experiments that graphene and its derivatives can promote cell adhesion, proliferation, differentiation and neurite growth effectively. They have good electrical conductivity, excellent mechanical properties, larger specific surface area, and other advantages when compared with traditional materials. The three-dimensional scaffold can improve the effect of nerve repair. Conclusion The metabolic pathways and long-term reaction of graphene and its derivatives in the body are unclear. How to regulate their biodegradation and explain the electric coupling reaction mechanism between cells and materials also need to be further explored.