黄酮类化合物的构效关系及其在肺部炎症疾病中的应用

Structure-activity relationship of flavonoids and its application in pulmonary inflammatory diseases

黄酮类化合物是自然界中存在的多酚类物质,根据化学结构可分为黄酮、二氢黄酮、黄酮醇、二氢黄酮醇、异黄酮、二氢异黄酮、黄烷-3-醇、花色素和查耳酮等类,且不同化学结构的黄酮类化合物多具有不同的生物活性。众多研究表明,黄酮类化合物具有抗氧化、抗突变、抗肿瘤、抗炎、抗菌、抗病毒和调节免疫等药理作用,其中抗炎和抗氧化特性使其成为预防和治疗肺部炎症疾病的潜在药物。重点综述了黄酮类化合物在肺部炎症疾病中的应用,并探讨了其抗炎和抗氧化特性的构效关系,以期为黄酮类化合物的开发利用提供参考。

As polyphenolic compounds in nature,flavonoids are classified into flavones,flavanones,flavonols,flavanonols,isoflavones,isoflavanones,flavan-3-ols,anthocyanidins,and chalcones according to their chemical structures.In general,flavonoids with different structures always have different biological activities.Many studies have shown that flavonoids exhibit a wide range of pharmacological effects,such as anti-oxidant,antimutagenic,antitumor,anti-inflammatory,antibacterial,antiviral,and immunomodulatory activities.The anti-inflammatory and anti-oxidant properties of flavonoids make them likely to be candidates for prevention and treatment of pulmonary inflammatory diseases.Thus,this review focuses on the application of flavonoids in pulmonary inflammatory diseases,as well as establishes some structure-activity relationships between this biological potential and chemical profile of these compounds,which can provide the references for the development and utilization of flavonoids.