黄芪联合丹参注射液在同步放化疗治疗宫颈癌中的作用观察

Astragalus membranaceus and Salvia miltiorrhiza injection combined with concurrent radiochemotherapy in treatment of patients with locally advanced cervical cancer

目的观察黄芪联合丹参注射液配合同步放化疗治疗局部中晚期宫颈癌患者的临床疗效、近远期毒副反应及生活质量改善。方法将收治的62例ⅡA-ⅣA期的宫颈癌病例按治疗方法分为试验组和对照组,其中对照组28例,采用同步放化疗治疗,试验组34例,行同步放化疗辅以中药黄芪和丹参注射液治疗,并对两组近远期疗效及胃肠道反应、骨髓抑制反应、慢性放射性肠炎和膀胱炎的发生率进行了比较。结果试验组近期有效率(97.01%)优于对照组(89.28%)(P<0.05)。试验组2年总生存率和无进展生存率分别为85.3%和76.5%,与对照组的82.1%和71.4%无明显差异(P>0.05),两组不同期别比较也无明显差异(P>0.05)。试验组急性胃肠道和骨髓抑制反应发生率分别为35.3%和23.5%,明显低于对照组的53.6%和35.7%(P均<0.05)。试验组慢性放射性肠炎和膀胱炎发生率分别为17.6%和5.9%,均低于对照组的28.6%和10.7%(P均<0.05)。结论黄芪联合丹参注射液配合同步放化疗可有效提高局部中晚期宫颈癌患者治疗疗效,减少毒副反应,并改善患者生活质量。

Objective To explore the clinical efficacy and quality of life of Astragalus membranaceus and Salvia miltiorrhiza injection combined with concurrent radiochemotherapy in treatment of patients with advanced cervical cancer.Methods 62 cervical cancer patients of ⅡA-ⅣA period from 2012-1 to 2013-12 were divided into two groups.34 cases were included to the group of Astragalus membranaceus and Salvia miltiorrhiza injection combined with concurrent radiochemotherapy（Observation group） and 28 cases were included to concurrent radiochemotherapy group（Control group）.The 2-year survival rate and adverse events were compared between two groups and the quality of life and side effects were observed.Results（1）The recent efficiency of Observation group（97.01%） was better than that of Control group（89.28%）（P〈0.05）.（2）The 2-year overall survival rate and Progression-free survival rate of the Observation group was not higher than those of Control group（85.3% VS 82.1%） and（76.5% VS 71.4%）（P〉0.05）.（3）3-4 grade of bone marrow suppression and grade 1-2 grade acute gastrointestinal reaction in the Observation group were lower than those of Control group（23.5% VS35.7%） and（35.3% VS53.6%）（P〈0.05）.（4）1-2 grade of chronic radiation enteritis and cystitis in the Observation group were lower than those of Control group（17.6% VS28.6%） and（5.9% VS10.7%）（P〈0.05）.Conclusion Astragalus membranaceus and Salvia miltiorrhiza injection combined with concurrent radiochemotherapy may enhance complete response,reduces the occurrence of side effects and improve quality of life in the treatment of patients with advanced cervical cancer.