乙型肝炎病毒X蛋白的研究进展

Advances in the study of the hepatitis B virus X protein

乙型肝炎病毒X基因编码的X蛋白是一种反式作用因子,具有调控细胞周期、胞内信号转导和凋亡以及诱导癌基因激活等多种生物学作用,对肝脏慢性炎症和肝细胞癌的发生有重要意义。本文就X蛋白在调控细胞凋亡、促进病毒复制和诱导肝细胞癌变方面的研究进展作一综述。

Hepatitis B virus X protein （HBx）, a viral protein encoded by the X gene of the hepatitis B virus, acts as a trans-acting factor. It performs a variety of biological actions, such as regulating the ceil cycle, intracellular signaling, induction of apoptosis, and oncogene activation, that play a crucial role in the development of chronic hepatitis and hepatocellular carcinoma. This review aims to summarize advances in the study of HBx in terms of regulating apoptosis, pro- moting viral replication, and inducing hepatocellular carcinogenesis.