细胞因子在巴贝虫感染中的作用研究进展

Advances in the study of the role of cytokines in babesiosis

巴贝虫感染伴随着复杂的免疫应答过程,细胞因子在巴贝虫感染过程中发挥着很重要的作用,与巴贝虫感染的发生、发展、预后有着密不可分的关系。本文主要从功能方面具体阐述TNF-α、IFN-γ以及白细胞介素等细胞因子在巴贝虫感染中发挥的作用。

Babesiosis is a tick-borne disease caused by the intraerythrocytic protozoan parasite Babesia. This disease is characterized by a host complex immune response that involves both cellular and humoral immunity. Cytokines play an important role in the process of Babesia infection and are closely related to the development and progression of babesiosis and its prognosis. Proinflammatory cytokines, such as TNF-α, IFN-γ, IL-2, and IL-12, are needed to initiate an effective inflammatory response and promote the elimination of Babesia parasites. In contrast, the cytokines IL-4 and IL-10 inhibit the cell-mediated inflammatory response by down-regulating the synthesis of pro-inflammatory cytokines. This article specifically describes, in terms of function, how TNF-α, IFN-γ, interleukins, and other cytokines play an important role in the development of babesiosis.