寻常性银屑病合并妊娠124例妊娠结局及其影响因素

The Pregnancy Outcomes of 124 Cases of Pregnancy Complicated with Psoriasis Vulgaris and Influencing Factors

目的探讨寻常性银屑病合并妊娠患者的妊娠结局及其影响因素。方法回顾性选取2015年1月-2018年1月在新乡医学院第一附属医院就诊的孕产妇临床资料,其中124例寻常性银屑病合并妊娠患者设为银屑病组,164例正常妊娠者设为对照组。比较两组发生的不良妊娠结局,并对可能影响银屑病组患者发生不良妊娠结局的临床特征进行单因素和多因素分析。结果银屑病组发生不良妊娠结局患者人数显著高于对照组,且差异具有统计学意义(P=0. 021);银屑病组不良妊娠结局指标如早产、低体重儿、新生儿窒息发生率均显著高于对照组,且差异具有统计学意义(P均<0. 05)。银屑病组新生儿体质量显著低于对照组,且差异具有统计学意义(P <0. 000)。单因素分析结果显示,寻常性银屑病合并妊娠患者的年龄、PASI评分、银屑病病程时间、银屑病复发频率和BMI与不良妊娠结局有关。多因素分析的结果显示,寻常性银屑病合并妊娠患者的PASI评分(OR=4. 773,P=0. 002)、银屑病病程时间(OR=3. 579,P=0. 001)和BMI(OR=5. 436,P=0. 002)与不良妊娠结局相关。结论寻常性银屑病合并妊娠患者的PASI评分、银屑病病程时间和BMI是发生不良妊娠结局的危险因素。

Objective To explore the pregnancy outcomes of pregnancy complicated with psoriasis vulgaris and the influencing factors. Methods A retrospective review about clinical data of 124 pregnant patients complicated with psoriasis vulgaris was performed from January 2015 to January 2018. The study included 124 pregnant patients complicated with psoriasis vulgaris as psoriasis group and 164 normal pregnant women as control group in our study. The adverse pregnancy outcomes were compared in both groups. The clinical characteristics of adverse pregnancy outcomes in the psoriasis group were analyzed by univariate analysis and multivariate regression analysis. Results The number of patients with adverse pregnancy outcomes in the psoriasis group was significantly higher than the control group, the difference was statistically significant （P =0. 021 ）. The indicators of adverse pregnancy outcomes such as preterm birth, low birth weight and neonatal asphyxia in psoriasis group were higher than the control group, and the differences were statistically significant （ all P 〈 0.05 ）. However, the neonatal weight in psoriasis group was lower than the control group, and the difference was statistically significant （ P 〈 0. 000 ）. Univariate analysis showed that age, PASI, duration and recurrence rate of psoriasis and BMI were correlated with adverse pregnancy outcomes. Multivariate analysis showed that PASI （ OR = 4. 773, P =0. 002） ,duration of psoriasis（ OR =3. 579 ,P =0. 001 ） and BMI（ OR =5. 436 ,P = 0. 002） were correlated with adverse pregnancy outcomes. Conclusion PASI, duration of psoriasis and BMI are the risk factors of adverse pregnancy outcomes.