源于组方优化设计的民族药研究思路与方法探讨

Research thinking and methods of ethnomedicine originated from optimization design of prescription

文章通过探讨中药二次开发和民族药复方使用现状,深入剖析民族药复方的特色和不足,提出民族药组方优化的必要性;在总结现有中药组方优化设计方法的基础上,阐述了源于设计的民族药组方优化思路,即从复方新药设计的源头开始,以确有疗效的民族药复方为优化对象,制定适宜的组方优化策略和方法,进行有目的地研究与升级改造;并提出了以"理清配伍关系、合理增减组成、核准配伍剂量、明确临床适应症"为目标的民族药组方优化基本原则和研究策略。

This paper discusses the secondary development of traditional Chinese medicine and the current situation of the use of ethnomedicines, while deeply analyzes the characteristics and shortcomings of ethnomedicine prescriptions to clarify the necessity of prescription optimization of ethnomedicine. On the basis of summarizing the optimization design methods of traditional Chinese medicine group prescriptions, we elaborate the idea of optimization of ethnomedicine prescriptions originated from the design. That is, starting from the source of the compound new drug design, taking the compound prescription of the ethnomedicines with definite curative effect as the optimization target, formulating appropriate strategies and methods to carry out targeted research and upgrading for the prescriptions; also propos the research strategy and basic principles of prescription optimization of ethnomedicine with the goal of ＇clarifying the relationship of compatibility, increasing and decreasing the composition rationally, approving the dose of compatibility and defining the clinical indications＇.