丹参酮Ⅱ_A对缺血性心脏病中细胞凋亡与自噬的调控机制研究进展

Research progress on regulation mechanism of tanshinone Ⅱ_A on cell apoptosis and autophagy in ischemic heart diseases

缺血性心脏病是全球发病率和致死率最高的疾病,严重地威胁着人类健康。丹参酮Ⅱ_A是从丹参的根部提取的主要亲脂性成分,研究表明,丹参酮Ⅱ_A具有多种抗心血管疾病的作用,其作用机制与调节心肌细胞的凋亡和自噬有关。论述了缺血性心脏病中细胞凋亡和自噬相关的信号通路及其相互关系,总结了近年来丹参酮Ⅱ_A通过调控细胞凋亡和自噬治疗缺血性心脏病的研究进展,探讨了其通过调控细胞凋亡和自噬从而产生心血管保护作用的机制,为深入研究缺血性心脏病以及药物的开发利用提供依据。

Ischemic heart disease is a leading cause of morbidity and mortality throughout the world which is a serious threat to human health. Tanshinone Ⅱ_A is a major lipophilic component extracted from the roots of Salvia miltiorrhiza. Studies have shown that tanshinone Ⅱ_A has a variety of anti-cardiovascular diseases, and its mechanism is related to the regulation of myocardial cell apoptosis and autophagy. This article discusses the signaling pathways and their correlations related to apoptosis and autophagy in ischemic heart disease. The recent advances about the regulation of apoptosis and autophagy in the treatment to ischemia heart disease by tanshinong Ⅱ_A were summarized. The mechanism of regulating apoptosis and autophagy to produce cardiovascular protection was discussed. This paper will provide a basis for in-depth study of ischemic heart disease and the development and utilization of drugs.