中医药防治局灶节段性肾小球硬化研究现状

Research status on prevention and treatment of traditional Chinese medicine on focal segmental glomerulosclerosis

局灶节段性肾小球硬化(FSGS)是常见的肾小球疾病,肾病综合征是其临床主要表现。肾脏预后主要与尿蛋白严重程度、肾功能状态及对药物治疗的反应相关。激素、免疫抑制剂等化学药的运用对部分FSGS患者的治疗效果欠佳,且副作用明显。近年来,随着对中医药治疗FSGS实验研究的深入和临床疗效的证明,中医药在延缓肾小球硬化、降低化学药副作用等方面具有很大优势。因此,对FSGS的中医药治疗现状进行综述。

Focal segmental glomerulosclerosis（FSGS） is a common glomerular disease, and nephrotic syndrome is the main clinical manifestation. The prognosis of the kidney is mainly related to proteinuria severity, renal function, and drug response. The use of chemical drugs such as hormones and immunosuppressants is not effective in the treatment of some FSGS patients, and the side effects are obvious. In recent years, with the in-depth research on the treatment of FSGS by traditional Chinese medicine and the proof of clinical efficacy, traditional Chinese medicine has great advantages in delaying glomerular sclerosis and reducing the side effects of chemical drugs. The present situation of Chinese medicine treatment in FSGS is reviewed in this paper.