介入治疗对糖尿病足患者血管功能及IL-6、TNF-α水平的影响

Effect of Interventional Therapy on Vascular Function and IL-6 and TNF-alpha Levels of Diabetic Foot Patients

目的探讨介入治疗对糖尿病足患者血管功能及IL-6、TNF-α水平的影响。方法选取我院2015年1月至2017年12月收治的糖尿病足患者112例作为研究对象,随机将患者分为观察组和对照组,每组各56例,观察组给予介入治疗,对照组给予常规治疗。采用彩色多普勒超声检测仪测量两组治疗前后内膜中层厚度、血管弹性程度及足背动脉血流速度。采用酶联免疫吸附法检测患者血清IL-6、TNF-α水平。结果治疗后两组内膜中层厚度、血管弹性程度及足背动脉血流速度指标均显著改善(P<0.05),观察组较对照组以上指标改善情况更加显著(P<0.05)。治疗后,两组血清IL-6和TNF-α水平明显降低,且观察组下降水平明显优于对照组(P<0.05)。结论介入治疗可有效减轻糖尿病足患者炎症反应,改善血管功能,疗效显著,可进一步在临床应用。

Objective to investigate effect of interventional therapy on vascular function and IL-6 and TNF-alpha levels of diabetic foot patients. Methods choose 112 cases diabetic foot patients treated in our hospital from January 2015 to December 2017 as research objects. Divide them into observation and control group randomly, 56 cases in each. Observation group was treated with interventional therapy, and control group with routine treatment. Detect intima media thickness, vascular elasticity and blood flow velocity of dorsalis pedis of two groups by color Doppler ultrasonography before and after treatment. Detect serum IL-6 and TNF-alpha levels with enzyme linked immunosorbent assay. Results after treatment, intima media thickness, vascular elasticity and blood flow velocity of dorsalis pedis of two groups was significantly improved（P〈0.05）. Improvement of above indexes of observation group was more significant than control group（P〈0.05）. After treatment, serum IL-6 and TNF-alpha levels of two groups were significantly decreased, and decrease level of observation group was significantly better than control group（P〈0.05）. Conclusion interventional therapy can reduce inflammatory reaction and improve vascular function effectively of diabetic foot patients, which can be further applied in clinical practice.