养阴方对实验性肝癌诱癌过程的影响

The Effect of Prescription of Nourishing Yin on Induced Course of Experimental Hepatocarcinoma

以DEN与AFB_1诱发大鼠肝癌为模型,通过病理形态与生化指标的观察,发现养阴方能减少模型鼠肝细胞异型性增生灶,降低肝组织GGT、GST与血清ALP活性升高的幅度,提示药物对癌前期病变形成有较明显的抑制作用。

Hepatocarcinoma model was induced in rats by diethylnitrosamine (DEN) and aflatoxin B1 (AFB1), and was observed by pathological picture and biochemical criterion. The result showed that the prescription of nourishing yin can reduce the dysplasia of hepatocyte in model rat, reduce the increase range of activity of GGT and GST in hepatic tissue, and it of ALP in serum. It showed that this prescription has remarkable inhibition to precan(?)erous lesion cerous lesion.