胰岛α细胞的功能调控研究进展

Research advances in functional regulation of islet α cells

胰岛α细胞功能失调参与糖尿病的发生。自身转录因子、转录后修饰、分泌相关转运体以及β、δ细胞的旁分泌信号、炎症因子和糖、脂、氨基酸等均可影响α细胞功能。本文就调控α细胞功能的多种因素及机制研究的最新进展进行综述。

Dysfuntion of α cells plays a critical role in the pathogenesis of diabetes. Its own transcription factors, posttranscriptional modification, transporters related to secretion and paracrine signals from 13 and δ cells, inflammatory factors, and carbohydrates, lipids, amino acids, all influence α cell function. We summaried the various factors involved in the regulation of α cell function as well as recent related advances on their molecular mechanisms.