骨再生与表观遗传调控研究进展

Progress in bone regeneration and epigenetic regulation

骨再生是骨组织受外力作用部分丢失后，重新形成形态与功能相同的骨组织的过程。骨再生旨在激发骨组织内在的再生能力，是一种治疗骨缺损或骨质疏松症极有前景的治疗手段。研究显示，许多表观遗传学机制均参与了骨再生的调控，包括DNA甲基化、组蛋白修饰和非编码RNA。这些表观遗传学机制可以通过不改变基因序列的方式而调节基因的表达，而且越来越多的研究证实了其在骨再生的重要性。本文将对近些年表观遗传学在骨再生领域的研究进展作一综述。

Bone regeneration is the process of reforming bone tissue with the same shape and function after partial loss of bone tissue by external force. Bone regeneration is a promising method for the treatment of bone defect or osteoporosis, which aims to stimulate the inherent regeneration ability of bone tissue. Studies have shown that many epigenetic mechanisms are involved in the regulation of bone regeneration, including DNA methylation, histone modification and non-coding RNA. Epigenetics refers to the changes in gene expression or phenotype without alterations in DNA sequence. Past studies have identified the importance of epigenetie mechanisms in bone regeneration. This article will review the research progress of epigenetics in bone regeneration in recent years.