二陈解鼾颗粒对阻塞性睡眠呼吸暂停低通气综合征患者炎症因子的影响

Effect of Erchen Snoring Granule on Inflammatory Factors in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

[目的]研究二陈解鼾颗粒对阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)痰湿内阻证患者肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、核转录因子-κB(nuclear transcription factor-κB,NF-κB)、白细胞介素-1(interleukin-1,IL-1)及白细胞介素-6(interleukin-6,IL-6)的影响。[方法]选择2015年12月至2016年12月在浙江中医药大学附属第一医院OSAHS专病门诊就诊的、符合诊断标准的痰湿内阻证OSAHS患者55例,通过随机数字法将患者随机分为治疗组及对照组。对照组27例患者予健康生活指导,治疗组28例患者在对照组治疗基础上予中药二陈解鼾颗粒治疗。两组疗程均为12周,检测两组患者治疗前后的睡眠呼吸暂停低通气指数(apnea hypopnea index,AHI)、呼吸紊乱时最低血氧饱和度(lowest oxygen saturation,LSaO2)、外周血炎症因子TNF-α、NF-κB、IL-1、IL-6水平的变化。[结果]治疗组患者AHI较治疗前明显改善,差异有统计学意义(P<0.05),而对照组治疗后无明显改善,与治疗前比较,差异无统计学意义(P>0.05)。治疗组患者外周血炎症因子TNF-α、NF-κB、IL-1、IL-6水平均有所下降,治疗前后对比差异具有统计学意义(P<0.05);而对照组治疗后炎症因子水平较治疗前稍升高,差异无统计学意义(P>0.05);且治疗后两组间比较差异有统计学意义(P<0.01)。[结论]二陈解鼾颗粒可有效改善睡眠呼吸暂停及睡眠低氧状态,可能是通过调节TNF-α、NF-κB、IL-1及IL-6水平,抑制炎症反应发挥治疗作用。

[Objective] To study the effect of Erchen snoring granule on inflammatory factors tumor necrosis factor-α（TNF-α）, nuclear transcription factor-κB（NF-κB）,interleukin-1（IL-1） and interleukin-6（IL-6）in patients with obstructive sleep apnea hypopnea syndrome（OSAHS） [Methods] Fifty five patients with OSAHS were selected who were diagnosed with phlegm and internal resistance syndrome who met the diagnostic criteria in the First Affiliated Hospital of Zhejiang Chinese Medical University from December 2015 to December 2016, and the patients were randomly divided into treatment groups and control groups by random number method. In control group, 27 patients were given guidance on healthy living, and 28 patients were treated with Chinese traditional medicine Erchen snoring granule on the basis of control group treatment. Both courses of treatment were 12 weeks, and tested the changes of sleep apnea hypopnea index（AHI） and minimum oxygen saturation（LSaO2） and peripheral blood inflammation factors TNF-α, NF-κB, IL-1,IL-6 before and after treatment in the two groups. [Results] The AHI in treatment group was significantly improved compared with that before treatment（P〈0.05）, but there was no significant improvement in control group after treatment（ P〈0.05）. The levels of TNF-α, NF-κB, IL-1, and IL-6 decreased in treatment group, and there was a statistically significant difference before and after treatment（ P0.05）. However, control group had a slight increase after treatment compared with that before treatment, but there was no statistical significance（ P〉0.05）, and there was a significant difference between the two groups after treatment（P〈0.01）. [Conclusion] Erchen snoring granule can effectively improve sleep apnea and sleep hypoxia. Erchen snoring granule can also regulate TNF-α, NF-κB, IL-1 and IL-6 levels, inhibit inflammatory reaction, and exert its therapeutic effect.