蒿属花粉特异性免疫治疗变应性鼻炎的临床疗效观察

Clinical observation on specific immunotherapy of allergic rhinitis with artemisia pollen

目的:观察蒿属花粉特异性免疫治疗变应性鼻炎的临床疗效。方法:选取变应原皮肤点刺试验蒿属花粉为阳性的变应性鼻炎患者139例,均行蒿属花粉特异性免疫治疗,间隔3个月复诊,分别于治疗前(N)、治疗开始后间隔3个月(D1,D2,D3)随访填写鼻症状总积分表(TNSS)、视觉模拟量表(VAS)评分、嗅觉功能分级、眼部症状评分(TOSS)及鼻结膜炎生活质量问卷(RQLQ)评分。结果:TNSS评分:N>D1,N>D2,N>D3,D1、D2、D3两两相比无差异;VAS评分:N>D1,N>D2,N>D3,D1、D2、D3两两相比无差异;嗅觉功能分级:N>D1,N>D2,N>D3,D1、D2、D3两两相比无差异;TOSS评分:N>D1,N>D2,N>D3,D1、D2、D3两两相比,其中D1>D2,其余无差异;RQLQ评分:N>D1,N>D2,N>D3,D1>D2,D3>D1,D3>D2。结论:蒿属花粉特异性免疫治疗对变应性鼻炎疗效确切,症状改善明显。

Objective： The aim of this study is to observe the clinical efficacy of pollen specific immunotherapy with Artemisia in allergic rhinitis. Method： A total of 139 patients with allergic rhinitis who were positive for Artemisia pollen were selected for allergen skin pricking. All of them were treated with Artemisia pollen-specific immunotherapy. The patients were followed up for 3 months, respectively before treatment （N）, after treatment start interval. 3 months （D1, D2, D3） follow-up fill in the total score of nasal symptoms （TNSS）, visual analogue scale （VAS） score, olfactory function grading, ocular symptom score （TOSS） and rhinoconjunctivitis quality of life questionnaire （RQLQ）） score. Result： TNSS： N〉D1, N〉 D2, N〉D3, D1, D2, D3 two of the three compared to no difference. VAS： N〉D1, N〉D2, N〉 D3, among D1, D2, D3, two of the three compared to no difference. Olfactory function classification： N〉D1, N〉D2, N〉D3, among D1, D2, D3, two of the three compared to no difference. TOSS ： N〉D1, N〉 D2, N〉D3, among D1, D2, D3, D1 〉D2, the rest had no difference. RQLQ ： N〉D1, N〉D2, N〉D3, D1〉D2, D3〉D1, D3〉D2. Conclusion： The specific pollen immunotherapy of artemisia is effective in the treatment of allergic rhinitis, and the symptoms are obviously improved.