一氧化氮监测在气道变应性疾病中的研究进展

The study of the nitric oxide monitoring in airway allergic diseases

气道变应性疾病是指特应性个体接触变应原后主要由IgE介导的一类气道慢性非感染性疾病,是一种以多种免疫活性细胞（肥大细胞、嗜酸粒细胞及淋巴细胞）及炎性递质共同参与的变态反应性疾病,主要包括下气道支气管哮喘（bronchial asthma,BA）和上气道变应性鼻炎（allergic rhinitis,AR）。目前一致认为BA和AR同属呼吸道变态反应性疾病,AR作为独立的重要危险因素可诱导BA的发生和发展[1-2],两者从发病部位、免疫病理学机制上均存在密切联系。

Airway allergic disease is a chronic non-infectious airway disease characterized by allergic airway inflammation and hyperresponsiveness.In recent years,the incidence of allergic diseases has increased year by year,and the pathogenesis is complex and not clear,which seriously affected the quality of life of patients and has become a global health problem that needs to be solved urgently.In recent years,scholars at home and abroad believe that the concentration of nitric oxide（NO）in oral and nasal exhaled can be used as an objective indicator to reflect the severity of upper and lower airway inflammation,and is a novel biomarker for noninvasive airway inflammation.This article reviews the clinical application of NO monitoring in allergic diseases and its research progress.