肠道菌群失调在肝硬化发生发展中的作用机制研究进展

Research progress on the mechanism of intestinal flora imbalance in the occurrence and development of liver cirrhosis

肝硬化是一种或多种原因引起的,以肝组织弥漫性纤维化、假小叶和再生结节为组织学特征的进行性慢性肝病,以肝功能减退和门静脉高压为主要表现,常并发上消化道出血、肝性脑病、继发感染等多种严重并发症而死亡。随着肠—肝轴理论的建立,笔者发现肠—肝轴与肝病的发病机制有着广泛的联系,在肝病中越来越成为临床研究的重点。临床上可以通过益生菌、益生元、粪便移植、中医药方法调节肠道菌群达到辅助治疗肝硬化及肝硬化并发症的目的。

Liver cirrhosis is caused by one or more reasons. liver dysfunction and portal hypertension are the main manifestations of progressive liver disease with histological features of diffuse liver fibrosis, false lobule, and regenerative nodules. This disease is often complicated by many serious complications such as gastrointestinal bleeding,hepatic encephalopathy, and secondary infection, which can lead to death. With the establishment of the intestinal-liver axis theory, it has been found that the intestinal-hepatic axis has a wide range of links with the pathogenesis of hepatic disease and has increasingly become the focus of clinical research in liver diseases. Clinically, probiotics, prebiotics, fecal transplants, and Chinese medicine methods can be used to adjust the intestinal flora to assist in the treatment of complications of cirrhosis and cirrhosis.