复方消化酶制剂对老年人消化功能减退的疗效及不良影响

Efficacy and Adverse Effects of Compound Digestive Enzyme Preparation on Digestive Dysfunction in the Elderly

目的研究复方消化酶制剂对老年人消化功能减退的疗效及不良影响。方法回顾性分析,选取2015年4月—2017年12月所在科室收诊的92例消化功能减退患者作为研究资料,以电脑随机分组后,对照组46例给予多潘立酮片治疗,观察组46例给予复方消化酶制剂治疗,而后对比两组治疗总有效率、治疗前后症状评分以及不良反应法发生率。结果观察组治疗总有效率为93.5%,显著高于对照组78.3%,观察组不良反应发生率为4.34%,显著低于对照组19.56%,差异有统计学意义(χ~2=4.389 5,5.159 5;P<0.05)。两组患者治疗后各项临床症状显著下降,观察组腹胀由治疗前(1.92±0.06)分下降至(1.04±0.22)分;食欲减退治疗前(1.78±0.61)分下降至(0.92±0.48)分;早饱评分治疗前(1.84±0.58)分下降至(0.92±0.38);恶心呕吐治疗前(1.52±0.52)分下降至(1.19±0.18)分,下降程度明显优于对照组,差异有统计学意义(P<0.05)。结论对于老年消化不良的患者采取复方消化酶制剂进行治疗可在短时间内促进食欲减退、腹胀等临床症状的消退,并提升治疗效果,安全、可靠,值得在消化系统疾病中应用推广。

Objective To study the efficacy and adverse effects of compound digestive enzyme preparations on digestivedysfunction in the elderly. Methods A retrospective analysis was performed on 92 patients with digestive dysfunctionwho were admitted to the department from April 2015 to December 2017. The data were randomly divided into groups.46 patients in the control group were treated with domperidone tablets, and 46 patients in the observation group, Thecompound digestive enzyme preparation was given for treatment, and then the total effective rate, the symptom scorebefore and after treatment, and the incidence of adverse reaction method were compared between the two groups. Re-sults The total effective rate of the observation group was 93.5%, which was significantly higher than that of the controlgroup （78.3%）. The incidence of adverse reactions in the observation group was 4.34%, which was significantly lowerthan that of the control group 19.56%, with statistical difference （χ2=4.389 5,5.159 5;P〈0.05）. The clinical symptomsof the two groups were significantly decreased after treatment. The abdominal distension of the observation group de-creased from （1.92±0.06）points to （1.04±0.22）points before treatment （1.78±0.61）points before the treatment of appetiteloss （0.92±0.48）points; Before the treatment （1.84±0.58）points, the score decreased to （0.92±0.38）points; before nauseaand vomiting （1.52±0.52）points, it decreased to（1.19±0.18）points, and the degree of decline was significantly better thanthat of the control group, with statistical difference（P〈0.05）. Conclusion The treatment of compound digestive enzymesin elderly patients with dyspepsia can promote the loss of clinical symptoms such as loss of appetite and abdominal dis-tension in a short period of time, and improve the therapeutic effect. It is safe and reliable and worthy of application inthe digestive diseases.