雷贝拉唑四联序贯疗法对于消化性溃疡合并慢性胃炎患者的疗效分析

Therapeutic Effect of Rabeprazole Quadruple Sequential Therapy on Patients with Peptic Ulcer Complicated with Chronic Gastritis

目的比较雷贝拉唑四联序贯疗法对于消化性溃疡合并慢性胃炎患者的疗效。方法选取2015年6月—2017年6月该院收治的150例消化性溃疡合并慢性胃炎患者,按照入院先后顺序采用数字随机分组方法 ,将其分为观察组以及对照组,每组75例,观察组给予雷贝拉唑四联序贯疗法,对照组给予奥美拉唑四联序贯疗法,比较两组的Hp消除率,临床症状恢复时间以及不良反应情况。结果观察组恶心呕吐消失时间(28.4±5.7)d腹痛缓解时间(32.5±4.7)d、嗳气消失时间(22.7±4.9)d、反酸消失时间(28.8±5.6)d、贫血改善时间(54.3±6.4)d,对照组恶心呕吐消失时间(41.3±6.9)d腹痛缓解时间(48.8±5.9)d、嗳气消失时间(38.3±6.3)d、反酸消失时间(36.9±6.8)d、贫血改善时间(72.4±8.8)d,均明显优于对照组,组间比较差异有统计学意义(t=15.659、22.238、19.686、8.842、16.578,P<0.05)。两组患者治疗结束后均复查电子胃镜并进行快速尿素酶检测了解Hp根除情况,观察组中56例患者达到Hp根除,根除率为74.67%,对照组中有40例患者在达到Hp根除,根除率为53.33%,组间比较差异有统计学意义(χ~2=6.983,P<0.05)。观察组并发症的发生率为32.00%(24/75),对照组并发症的发生率为68.00%(51/75),组间比较差异有统计学意义(χ~2=17.618,P<0.05)。结论雷贝拉唑四联治疗方式应用于消化性溃疡合并慢性慢性胃炎治疗的Hp根除率明显升高,且不良反应少,短时间内可改善临床症状,属于高效安全的治疗方案,值得临床推广和应用。

Objective To compare the efficacy of rabeprazole quadruple sequential therapy for patients with peptic ul-cer complicated with chronic gastritis. Methods A total of 150 patients with peptic ulcer and chronic gastritis admittedto the hospital from June 2015 to June 2017 were randomly divided into observation group and control group accordingto the order of admission. For example, the observation group was given rabeprazole quadruple sequential therapy, andthe control group was given omeprazole quadruple sequential therapy. The Hp elimination rate, clinical symptom recov-ery time and adverse reaction were compared between the two groups. Results The disappearance time of nausea andvomiting in observation group was （28.4±5.7）d, the relief time of abdominal pain was （32.5±4.7）d, the time of disap-pearance of hernia was （22.7±4.9）d, the time of disappearance of acid reflux was （28.8±5.6）d, the time of improve-ment of anemia was （54.3±6.4）d. The nausea and vomiting disappearance time in the control group was （41.3±6.9）dabdominal pain relief time （48.8±5.9）d, hernia disappearance time（38.3±6.3）d, acid reflux disappearance time （36.9±6.8）d, anemia improvement time （72.4±8.8）d, were significantly better than the control group, the difference betweenthe groups was statistically significant （t=15.659 22.238, 19.686, 8.842, 16.5778,P约0.05）. After the end of treatment,the two groups of patients underwent electronic gastroscopy and rapid urease test to understand the eradication of Hp.56 patients in the observation group achieved Hp eradication, the eradication rate was 74.67%, and 40 patients in thecontrol group achieved Hp eradication and eradication. The rate was 53.33%, and the difference between the groupswas statistically significant （χ2=6.983, P<0.05）. The incidence of complications in the observation group was 32.00%（24/75）, and the incidence of complications in the control group was 68.00% （51/75）. The difference between the twogroups was statistically significant （χ2=17.618, P<0.05）. Conclusion Rabeprazole quadruple therapy is effective in thetreatment of peptic ulcer with chronic chronic gastritis. The Hp eradication rate is obviously increased, and the adversereactions are few. It can improve the clinical symptoms in a short time. It is an effective and safe treatment plan, whichis worthy of clinical practice promotion and application.