小核糖核酸21与肺癌的研究进展

Research progress in miRNA-21 and its association with lung cancer

近年通过基因芯片技术研究小核糖核酸(miRNA)与疾病的关系受到越来越多的关注,miRNA-21为miRNA家族中的一员,具有多种生物学功能,已被证实参与多种疾病的发生和发展。研究表明,miRNA-21可作为肺癌进展的生物标志物,为肺癌进展的早期干预提供一种可能,本文综述了miRNA-21与肺癌的研究进展。

In recent years, more and more attention has been drawn to the research on the association of micro ribonucleic acid （miRNA） with diseases using gene-chip technology. miRNA-21, a member of the miRNA family, has many biological functions and has been proven to be associated with the occurrence and development of a good number of diseases. Studies have suggested that miRNA-21 can be used as a biomarker for the progression of lung cancer, providing a possibility for early intervention in the progression of lung cancer. This paper reviewed the recent progress made in the research on miRNA-21 and lung cancer.