摘要
脊髓小脑共济失调3型(SCA3)是遗传性共济失调的最常见的类型,主要通过损害小脑、脑桥及其相应的核团和通路而导致患者产生共济失调等运动症状和认知功能障碍等非运动症状。本文就SCA3患者产生认知功能障碍的临床表现、病理学基础、发病机制及治疗方法等方面予以综述。
Spinocerebellar ataxia type 3 (SCA3) is the most common type of hereditary ataxia,which causes motor symptoms such as ataxia and non motor symptoms such as cognitive dysfunction by damaging the cerebellum,pons and their corresponding nuclei and pathways.This article reviews the clinical manifestations,pathological basis,pathogenesis and treatment methods of cognitive dysfunction in SCA3 patients.
作者
李陶乐
张林明
LI Taole;ZHANG Linming(Department of Neurology,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)
出处
《中国实用神经疾病杂志》
2018年第19期2104-2108,共5页
Chinese Journal of Practical Nervous Diseases
基金
云南省科技厅-昆明医科大学应用基础研究联合基金资助(项目编号:2015FB044)