HBV相关性肝病患者HBsAg水平与HCCR、AFP的相关性及其肝功能指标的变化情况

Correlation of HBsAg level with HCCR,AFP and the changes of liver function in patients with HBV related liver disease

目的探讨乙型肝炎病毒(HBV)相关性肝病患者乙肝病毒表面抗原(HBsAg)水平与人宫颈癌基因(HCCR)、甲胎蛋白(AFP)的相关性及其肝功能指标的变化情况。方法选取318例HBV相关性肝病患者为病例组,选取60例健康人群为对照组。比较两组HCCR、AFP检测结果,并分析HBsAg水平与HCCR、AFP的相关性;比较不同血清HBsAg水平患者以及不同HBV相关性肝病患者的HCCR、AFP检测阳性率;比较两组的丙氨酸氨基转移酶(ALT)、谷氨酸转肽酶(GGT)以及碱性磷酸酶(ALP)检测结果。结果病例组HCCR和AFP水平均显著高于对照组,差异有统计学意义(P<0.05);不同HBsAg水平患者的HCCR与AFP水平均呈正相关关系(P<0.05);随着HBsAg水平的升高,HCCR、AFP水平和阳性率均显著升高,差异有统计学意义(P<0.05);乙型肝炎、肝硬化、原发性肝癌患者的HCCR、AFP阳性率依次显著升高,差异有统计学意义(P<0.05);病例组ALT、GGT、ALP水平显著高于对照组,差异有统计学意义(P<0.05);原发性肝癌患者GGT水平显著高于乙型肝炎、肝硬化患者,而ALT水平则显著低于乙型肝炎、肝硬化患者,差异有统计学意义(P<0.05)。结论 HCCR、AFP水平与HBsAg水平呈正相关,反映了HBV相关性肝病患者肝细胞病变的严重程度。对于HBsAg高水平患者,应联合检测HCCR、AFP以及早明确肝脏病变情况,提高肝癌的防治效果。

Objective To investigate the correlation of hepatitis B virus surface antigen （HBsAg） level with human cervical cancer gene （HCCR） and alpha fetoprotein （AFP） and the changes of liver function in pa tients with hepatitis B virus （HBV） related liver disease. Methods 318 patients with HBV related liver dis ease were selected as the case group, and 60 healthy people were selected as the control group. The levels of HCCR and AFP between the two groups were compared. The correlation of HCCR and AFP in patients with different HBsAg levels were analyzed. The positive rates of HCCR and AFP in patients with different HBsAg levels and different HBV related liver diseases were compared. The levels of alanine aminotransferase （ALT） , glutamate transpeptidase （GGT） and alkaline phosphatase （ALP） in the two groups were compared. Results The levels of HCCR and AFP in the case group were significantly higher than those in the control group, and the differences were statistically significant （P〈0.05）. The levels of HCCR and AFP were positively correla ted in patients with different HBsAg levels （P〈0.05）. With the HBsAg level increased,the levels and the positive rates of HCCR and AFP were significantly increased,and the differences were statistically significant （P〈0.05）. The positive rates of HCCR and AFP in hepatitis B,cirrhosis and hepatocellular carcinoma were significantly increased in turn （P〈0.05）. The levels of ALT,GGT and ALP in the case group were signifilevel of GGT of patients with hepatocellular carcinoma was significantly higher than that of patients with hep atitis B and liver cirrhosis,while the level of ALT was significantly lower than that of patients whit hepatitis B and liver cirrhosis,and the differences were statistically significant （P〈0.05）. Conclusion The levels of HC CR and AFP are positively correlated with the level of HBsAg,which reflects the severity of liver cell lesions in patients with HBV related liver disease. For patients with high levels of HBsAg,the combined detection of HCCR and AFP is helpful to clarify the lesion of liver and improve the prevention effect of hepatocellular car cinoma.