Dax1与胚胎干细胞多能因子Oct4、Sox2、Nanog及Esrrb相互作用的研究进展

Advances in the interaction of Dax1 with embryonic stem cells multipotential network factors Oct4, Sox2, Nanog, and Esrrb

胚胎干细胞(ESCs)的自我更新能力和多能性的维持依靠Oct4、Sox2、Nanog及Esrrb等转录因子形成的庞大、复杂的转录调节网络,而Dax1也能参与ESCs特性调节。Dax1与Oct4、Sox2、Nanog和Esrrb等核心因子相互作用,参与维持ESCs特性并抑制ESCs分化。Dax1还能在诱导产生诱导多能干细胞(IPSCs)过程后期产生与Nanog相似的促进作用。研究Dax1在ESCS转录调节网络和诱导产生IPSCs过程中的作用、功能、地位和与其他转录因子相互作用的具体机制,可为干细胞机制研究和临床治疗转化研究助力。目前,Dax1在胚胎干细胞中作用的相关研究较少。本文综述了已有研究成果,以期为胚胎干细胞进一步研究及临床治疗转化研究提供参考。

The self-renewal and pluripotency of embryonic stem cells （ESCs） are maintained by the large and complex interconnected transcriptional regulatory network formed by transcription factors such as Oct4, Sox2, Nanog, and Esrrb, and Dax1 can also participate in the regulation of ESCs. Dax1 interacts with core factors such as Oct4, Sox2, Nanog and Esrrb, and participates in maintaining characteristics of ESCs and inhibiting ESCs differentiation. Dax1 can also produce a similar promotion to Nanog in the later stages of induction of induced pluripotent stem cells （IPSCs）. To study the role, function, status and interaction of Dax1 in the ESCS transcriptional regulatory network and the induction of IPSCs, and the specific mechanisms of interaction with other transcription factors can be helpful for stem cell mechanism research and clinical therapeutic transformation research. At present, there are few studies on the role of Dax1 in embryonic stem cells. This paper reviews the existing research results in order to provide reference for further research and clinical treatment transformation of embryonic stem cells.