甲状腺乳头状癌分子生物学标志物的研究进展

Research Progress of Molecular Biomarkers for Papillary Thyroid Cancer

甲状腺癌是内分泌科中最常见的恶性肿瘤,而甲状腺乳头状癌(PTC)是甲状腺癌最常见的病理类型。目前PTC在临床上缺乏早期实验室检验指标,但伴随着实验室检测技术不断进步,PTC分子生物学标志物的研究在近年来取得了较大进展,其中包括微RNA、生化标志物以及基因标志物,这些标志物在PTC中均有异常表达,且与肿瘤的发生、发展密切相关,PTC分子生物学标志物有望成为诊断PTC的新标准。深入研究PTC分子生物学标志物可为临床医师提供肿瘤发病情况的实时信息,发现早期肿瘤提供有力的证据。

Thyroid cancer is the most common malignant tumor in endocrinology,and papillary thyroid carcinoma（PTC） is the most common pathological type.At present,PTC is lack of early laboratory test index.However,with the continuous improvement of laboratory detection technology,the study on molecular biomarkers of PTC had made great progress in recent years,including miRNA,biochemical markers and genetic markers.These markers had abnormal expression in PTC,and were closely related with the occurrence and development of tumors.Molecular biomarkers of PTC are expected to be a new standard for the diagnosis of PTC.The study on molecular biomarkers of PTC provides clinicians with real-time information on the incidence of tumors and provides more powerful evidence for the detection of early tumors.