维甲酸与炎症性肠病的相关研究进展

Research Progress in the Correlation between Retinoic Acid and Inflammatory Bowel Disease

炎症性肠病(IBD)是一种病因尚不十分明确的慢性反复性非特异性胃肠道炎症性疾病,包括溃疡性结肠炎和克罗恩病。溃疡性结肠炎是一种慢性非特异性的结肠炎症,重者发生溃疡。克罗恩病是一种慢性肉芽肿性炎症,多呈节段性,非对称性分布,多数研究认为是由多种因素相互作用所致。维甲酸与IBD关系密切,可通过调节IBD中细胞因子以及相关的非特异免疫细胞来减少炎症,通过免疫调节对IBD有治疗作用。国内研究多集中于维甲酸通过免疫调节机制缓解IBD,而维甲酸如何通过非特异性免疫机制作用于IBD的研究较少。

Inflammatory bowel disease（IBD） is a gastrointestinal inflammatory disease of chronic repeatability,causes of which are not very clear and non-specific,and it includes ulcerative colitis and Crohn disease. The former is a chronic nonspecific inflammation of the colon, and ulcers may occur in serious cases.The latter is a chronic granulomatous inflammation,presenting the segmental,asymmetric distribution,thought to be caused by the interaction of many factors in most studies.Retinoic acid is closely associated with IBD,which reduces inflammation mainly by adjusting the related cytokines in IBD and nonspecific immune cells.Studies in China are mainly concentrated on retinoic acid alleviating IBD by immunomodulatory mechanism,while studies on how retinoic acid acts on IBD by nonspecific immune mechanism are much less.