心力衰竭新型治疗药物沙库巴缬沙坦的研究进展

Research Progress of Sacubitril/Valsartan—A New Type of Drug for Heart Failure

沙库巴曲缬沙坦是一种新型的治疗心力衰竭药物。该药由作用于脑啡肽酶的沙库巴曲和作用于肾素-血管紧张素-醛固酮系统的缬沙坦组成,该药物主要通过抑制脑啡肽酶和肾素-血管紧张素-醛固酮系统而发挥作用。与依那普利相比,沙库巴曲缬沙坦可进一步降低心血管死亡或心力衰竭住院风险和全因死亡风险,堪萨斯城心肌病问卷总评分下降更多。与依那普利相比,沙库巴曲缬沙坦有更好的安全性和耐受性。目前,沙库巴曲缬沙坦获得了欧美指南一致推荐。

Sacubitril/valsartan is a new type of drug for heart failure.It is composed of sacubitril which acts on enkephalinase and valsartan which acts on renin-angiotensin-aldosterone system.Its main action mechanism is to inhibit enkephalinase and renin-angiotensin-aldosterone system.Sacubitril/valsartan can further reduce the risks of cardiovascular death and hospitalization and all-cause death compared with enalapril,with a much decreased total score of the Kansas city cardiomyopathy questionnaire.The safety and tolerability of sacubitril/valsartan is better than enalapril.At present,this medicine has been recommended by European and American guidelines.