Erectile dysfunction in hemodialysis: A systematic review

Men with chronic renal failure(CRF)on hemodialysis have been frequently associated with erectile dysfunction(ED),with an of between 20%to 87.7%.As a result of the multi-system disease processes present in many uremic men,it is apparent that the pathogenesis of ED is most probably multifactorial.Factors to be considered include peripheral vascular disease,neurogenic abnormalities,hormonal disturbances and medications used for treatment of conditions associated with CRF.These physiological abnormalities may be supplemented by significant psychological stresses and abnormalities resulting from chronic illness.Treatment must start with the determination and treatment of the underlying causes.In addition to psychological treatment,further lines of treatment of ED in CRF can be classified as 1st line(medical treatment which includes oral phosphodiesterase-5 inhibitors and hormone regulation),2nd line(intracavernosal injection,vacuum constriction devices and alprostadil urethral suppositories)or 3rd line(surgical treatment).Renal transplantation improves the quality of life for some patients with CRF and subsequently it may improve erectile function in a significant number of them,however still there is high incidence of ED after transplantation.

Men with chronic renal failure （CRF） on hemodialysis have been frequently associated with erectile dysfunc-tion （ED）, with an of between 20% to 87.7%. As a result of the multi-system disease processes present in many uremic men, it is apparent that the pathogenesis of ED is most probably multifactorial. Factors to be con-sidered include peripheral vascular disease, neurogenic abnormalities, hormonal disturbances and medications used for treatment of conditions associated with CRF. These physiological abnormalities may be supplement-ed by signifcant psychological stresses and abnormali-ties resulting from chronic illness. Treatment must start with the determination and treatment of the underlying causes. In addition to psychological treatment, furtherlines of treatment of ED in CRF can be classifed as 1stline （medical treatment which includes oral phosphodi-esterase-5 inhibitors and hormone regulation）, 2nd line（intracavernosal injection, vacuum constriction devicesand alprostadil urethral suppositories） or 3rd line （sur-gical treatment）. Renal transplantation improves thequality of life for some patients with CRF and subse-quently it may improve erectile function in a signifcantnumber of them, however still there is high incidenceof ED after transplantation.