摘要
MicroRNAs have become recognized as key players in the development of cancer. They are a family of small non-coding RNAs that can negatively regulate the expression of cancer-related genes by sequence-selective targeting of mRNAs, leading to either mRNA degradation or translational repression. Lung cancer is the leading cause of cancer-related death worldwide with a substantially low survival rate. MicroRNAs have been confirmed to play roles in lung cancer develop-ment, epithelial-mesenchymal transition and response to therapy. They are also being studied for their future use as diagnostic and prognostic biomarkers and as potential therapeutic targets. In this review we focus on the role of dysregulated microRNA expression in lung tumorigenesis. We also discuss the role of microRNAs in therapeutic resistance and as biomarkers. We further look into the progress made and challenges remaining in using microRNAs for therapy in lung cancer.
作者
Pooja Joshi
Justin Middleton
Young-Jun Jeon
MichelaGarofalo
Pooja Joshi;Justin Middleton;Young-Jun Jeon;Michela Garofalo(Department of Molecular Virology,Immunology and Medical Genetics,Comprehensive Cancer Center,The Ohio State University Wexner Medical Center;The Ohio State University,Columbus,OH 43210,United States;Transcriptional Networks in Lung Cancer Group,Cancer Research UK Manchester Institute,University of Manchester,Manchester M20 4BX,United Kingdom)
